Basal ryanodine receptor activity suppresses autophagic flux
نویسندگان
چکیده
منابع مشابه
Flux regulation of cardiac ryanodine receptor channels
The cardiac type 2 ryanodine receptor (RYR2) is activated by Ca2+-induced Ca2+ release (CICR). The inherent positive feedback of CICR is well controlled in cells, but the nature of this control is debated. Here, we explore how the Ca2+ flux (lumen-to-cytosol) carried by an open RYR2 channel influences its own cytosolic Ca2+ regulatory sites as well as those on a neighboring channel. Both flux-d...
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متن کاملAcute hyperglycemia suppresses left ventricular diastolic function and inhibits autophagic flux in mice under prohypertrophic stimulation
BACKGROUND Left ventricular (LV) dysfunction is closely associated with LV hypertrophy or diabetes, as well as insufficient autophagic flux. Acute or chronic hyperglycemia is a prognostic factor for patients with myocardial infarction. However, the effect of acute hyperglycemia on LV dysfunction of the hypertrophic heart and the mechanisms involved are still unclear. This study aimed to confirm...
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ژورنال
عنوان ژورنال: Biochemical Pharmacology
سال: 2017
ISSN: 0006-2952
DOI: 10.1016/j.bcp.2017.03.011